國家衛生研究院 NHRI:Item 3990099045/14621
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    題名: Poly(acrylic acid)-grafted metal-organic framework carrying Mg ions for bone repair
    作者: Yu, YS;Hsu, CH;Cheng, PH;Wu, KCW;Liu, CH
    貢獻者: Institute of Biomedical Engineering and Nanomedicine
    摘要: In the field of biomedicine, metal-organic frameworks (MOFs) have been extensively studied. However, few studies have applied them to bone healing. In recent years, iron-based MOFs such as MIL-100(Fe) have been proven biocompatible and suitable for drug delivery applications. We used water-phase synthesis methods to prepare MIL-100(Fe) and NH2 functionalized MIL-100(Fe). We then performed post-synthesis modification to incorporate Magnesium (Mg) ions into the cages of the MIL-100(Fe) (i.e., Mg@MIL-100(Fe)). The poly(acrylic acid) (PAA) modification on the surface of Mg@MIL-100(Fe) (i.e., Mg@MIL-100(Fe)-PAA) prevented the Mg ions from leaking, thus significantly increasing the Mg loading. The cytotoxicity test of the osteoblast-like cell line MG-63 showed that Mg@MIL-100(Fe)-PAA was biocompatible and could slightly improve cell proliferation. Furthermore, the ALP assay showed that Mg@MIL-100(Fe)-PAA could alter the time course of cell differentiation, which could eventually accelerate the bone healing process. These findings revealed the potential of utilizing metal-organic frameworks as bone repairing materials.
    日期: 2022-12-01
    關聯: Materials Chemistry and Physics. 2022 Dec 1;292:Article number 126840.
    Link to: http://dx.doi.org/10.1016/j.matchemphys.2022.126840
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0254-0584&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000869096600005
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85139312583
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