國家衛生研究院 NHRI:Item 3990099045/14486
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14486


    Title: Risk of dementia after exposure to contrast media: A nationwide, population-based cohort study
    Authors: Yu, TM;Chuang, YW;Huang, ST;Huang, JA;Chen, CH;Chung, MC;Wu, CY;Chang, PY;Hsu, CC;Wu, MJ
    Contributors: Institute of Population Health Sciences
    Abstract: Contrast-medium-associated kidney injury is caused by the infusion of contrast media. Small vessel disease is significantly associated with various diseases, including simultaneous conditions of the kidney and brain, which are highly vulnerable to similar vascular damage and microvascular pathologies. Data to investigate the adverse effect of contrast media on the brain remain extremely lacking. In this study, 11,332,616 NHI enrollees were selected and divided into two groups, exposed and not exposed to a contrast medium during the observation period, from which 1,461,684 pairs were selected for analyses through matching in terms of age, sex, comorbidities, and frequency of outpatient visits during the previous year. In total, 1,461,684 patients exposed to a contrast medium and 1,461,684 controls not exposed to one were enrolled. In multivariable Cox proportional hazard models, patients exposed to a contrast medium had an overall 2.09-fold higher risk of dementia. In multivariable-stratified analyses, the risk of Alzheimer's disease was remarkably high in younger patients without any underlying comorbidity. This study is the first to discover that exposure to contrast media is significantly associated with the risk of dementia. A four-fold increased risk of vascular dementia was observed after exposure to a contrast medium. Further studies on the influence of exposure to contrast media on the brain are warranted.
    Date: 2022-08-19
    Relation: Biomedicines. 2022 Aug 19;10(8):Article number 2015.
    Link to: http://dx.doi.org/10.3390/biomedicines10082015
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2227-9059&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000846222700001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85137356970
    Appears in Collections:[Chih-Cheng Hsu] Periodical Articles

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