國家衛生研究院 NHRI:Item 3990099045/14479
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    题名: Phylogenetic characteristics of non-SARS human coronavirus in Southern Taiwan, 2012-2013
    作者: Wang, HC;Wang, YC;Wu, CJ
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: This study characterizes the phylogenetic relatedness of non-SARS human coronaviruses (HCoVs) in Southern Taiwan by sequencing the nucleocapsid (N), spike (S), and RNA-dependent RNA polymerase (RdRp) genes directly from ten HCoV PCR-positive respiratory samples collected during 2012-2013. In the N, S1, and RdRp phylogeny, HCoV-OC43 in one and three samples was clustered with genotypes F and G, respectively, and HCoV-OC43 in sample YC101/TWN/2013 represented a recombination event between genotypes F and G. Amino acid substitutions in the S1 protein of HCoV-OC43 were also identified. In the N phylogeny, HCoV-HKU1 in one and two samples clustered with genotypes A and B, respectively, and HCoV-229E in two samples was clustered with genogroup 6. The genotypes and genogroup detected here were in line with the prevalent phylogenetic lineages reported outside of Taiwan during the contemporary period. In summary, three species of non-SARS HCoVs with different genotypes cocirculated in the community, with genetic evolution observed in HCoV-OC43.
    日期: 2022-08-11
    關聯: Biomedical Journal. 2022 Aug 11;46(4):Article number 100555.
    Link to: http://dx.doi.org/10.1016/j.bj.2022.08.001
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2319-4170&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001028077900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85146982420
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