國家衛生研究院 NHRI:Item 3990099045/14473
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    题名: Correspondence to 'Bacterial citrullinated epitopes generated by Porphyromonas gingivalis infection-a missing link for ACPA production'
    作者: Ma, KSK;Chiang, CH;Chen, YW;Wang, LT
    贡献者: Institute of Cellular and Systems Medicine
    摘要: With great interest, we read the work by Jenning et al, which proposed a mechanism by which Porphyromonas gingivalis (P.g.) is involved in rheumatoid arthritis (RA) progression by citrullinating and producing exogenously citrullinated human and bacterial epitopes.1 This commendable work elucidated the mechanism by which autocitrullinated prokaryotic peptidyl arginine deiminase (PPAD) mediates the inflammatory pathogenesis of RA. In particular, the authors demonstrated a correlation between anti-RA-PPAD and both anticitrullinated peptide/protein antibody (ACPA) levels and interstitial lung disease autoantigen reactivity. The study also provided evidence regarding how PPAD citrullinates the internal arginines of RA autoantigens.1 Moreover, the findings of this study suggested that the failure to clear P.g. induces bacterial citrullinated epitope-specific ACPAs, which might trigger ACPA-mediated autoimmunity.1 P.g. is the main pathogen responsible for periodontitis and has been proposed to be involved in stimulating self-reactive immune responses,2 3 which underlie the association between RA and periodontitis.4 We are highly interested in the upstream and downstream cellular mechanisms of ACPA development in patients with RA. We compared the transcriptome profiles of human blood samples from patients with RA and human gingival tissues from periodontitis patients registered in the National Center for Biotechnology Information-Gene Expression Omnibus database. Overall, we identified 14 periodontitis-associated pathways that were significantly expressed during RA pathogenesis using p-value and Z-score visualisation. As shown in figures 1, eight pathways were upregulated with positive Z-scores. Among the eight periodontitis-associated pathways upregulated during RA pathogenesis, we found host responses against bacterial infections that were associated with ACPA development, including oxidative stress responses in macrophages,5–7 B cell receptor signalling,8–10 and lipopolysaccharides/interleukin (IL)-1-mediated pathways. These findings are consistent with previous studies reporting that inducible nitric oxide synthase (iNOS)-producing inflammatory M1 macrophages are responsible for autoimmunity, including that of RA,11 and that glycosylated ACPA IgG molecules8 are extensively expressed by autoreactive memory B cells.8–10 Likewise, IL-8, a proinflammatory CXC chemokine responsible for recruiting leukocytes,12 was also upregulated during RA onset. Thus, it is possible that the initiation of RA onset following P.g. infection involves these immune responses. Since signalling pathways associated with both IL-8 and leucocyte extravasation were upregulated, it can be inferred that infiltrating leucocytes may contribute to or be associated with ACPA development.
    日期: 2023-10
    關聯: Annals of the Rheumatic Diseases. 2023 Oct;82(10):Article number e216.
    Link to: http://dx.doi.org/10.1136/annrheumdis-2020-219255
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0003-4967&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000726529100001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85117110313
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