國家衛生研究院 NHRI:Item 3990099045/14460
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    题名: Disclosing an in-frame deletion of the titin gene as the possible predisposing factor of anthracycline-induced cardiomyopathy: A case report
    作者: Chang, YW;Weng, HY;Tsai, SF;Fan, FS
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: Anthracycline-induced cardiomyopathy has been noted as a non-neglectable issue in the field of clinical oncology. Remarkable progress has been achieved in searching for inherited susceptible genetic deficits underlying anthracycline cardiotoxicity in the past several years. In this case report, we present the preliminary results of a genetic study in a young male patient who was treated with standard dose anthracycline-based chemotherapy for his acute myeloid leukemia and attacked by acute congestive heart failure after just two courses of therapy. After a survey of 76 target genes, an in-frame deletion of the titin gene was recognized as the most possible genetic defect responsible for his cardiomyopathy caused by anthracycline. This defect proved to pass down from the patient's mother and did not exist in seven unrelated chemotherapy-treated cancer patients without chemotherapy-induced cardiomyopathy and four other healthy volunteer DNA donors.
    日期: 2022-08-17
    關聯: International Journal of Molecular Sciences. 2022 Aug 17;23(16):Article number 9261.
    Link to: http://dx.doi.org/10.3390/ijms23169261
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000846521400001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85137708193
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