國家衛生研究院 NHRI:Item 3990099045/14448
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14448


    Title: Development of injectable calcium sulfate and self-setting calcium phosphate composite bone graft materials for minimally invasive surgery
    Authors: Chiu, YH;Chen, IC;Su, CY;Tsai, HH;Young, TH;Fang, HW
    Contributors: Institute of Biomedical Engineering and Nanomedicine
    Abstract: The demand of bone grafting is increasing as the population ages worldwide. Although bone graft materials have been extensively developed over the decades, only a few injectable bone grafts are clinically available and none of them can be extruded from 18G needles. To overcome the existing treatment limitations, the aim of this study is to develop ideal injectable implants from biomaterials for minimally invasive surgery. An injectable composite bone graft containing calcium sulfate hemihydrate, tetracalcium phosphate, and anhydrous calcium hydrogen phosphate (CSH/CaP paste) was prepared with different CSH/CaP ratios and different concentrations of additives. The setting time, injectability, mechanical properties, and biocompatibility were evaluated. The developed injectable CSH/CaP paste (CSH/CaP 1:1 supplemented with 6% citric acid and 2% HPMC) presented good handling properties, great biocompatibility, and adequate mechanical strength. Furthermore, the paste was demonstrated to be extruded from a syringe equipped with 18G needles and exerted a great potential for minimally invasive surgery. The developed injectable implants with tissue repairing potentials will provide an ideal therapeutic strategy for minimally invasive surgery to apply in the treatment of maxillofacial defects, certain indications in the spine, inferior turbinate for empty nose syndrome (ENS), or reconstructive rhinoplasty.
    Date: 2022-07-08
    Relation: International Journal of Molecular Sciences. 2022 Jul 8;23(14):Article number 7590.
    Link to: http://dx.doi.org/10.3390/ijms23147590
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000833290100001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85133679147
    Appears in Collections:[Others] Periodical Articles

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