國家衛生研究院 NHRI:Item 3990099045/1442
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1442


    Title: Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population
    Authors: Loh, EW;Tang, NLS;Lee, DTS;Liu, SI;Stadlin, A
    Contributors: Division of Mental Health and Addiction Medicine
    Abstract: GABA(A) receptor subunit genes clustered on 5q33 play a role in the development of alcoholism and methamphetamine use disorder without psychosis. The present study explored the possible contribution of the same subunit genes to the development of heroin dependence. Single nucleotide polymorphisms (SNPs) of the GABAA receptor subunits GABRB2, GABRA6, GABRA1, and GABRG2 were examined in 178 male Han Chinese heroin-dependent and 170 male control subjects. A significant difference in allele frequency for the SNP rs211014 in the GABA(A)gamma 2 receptor subunit gene between cases and controls was identified (P=0.015). A possible mechanism for the involvement of the GABA receptor subunit genes on 5q33 in the development of heroin dependence is discussed. (c) 2007 Wiley-Liss, Inc.
    Keywords: Genetics & Heredity;Psychiatry
    Date: 2007-06-05
    Relation: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2007 Jun;144B(4):439-443.
    Link to: http://dx.doi.org/10.1002/ajmg.b.30429
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1552-4841&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000246982700007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34250801588
    Appears in Collections:[El-Wui Loh(2004-2012)] Periodical Articles

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