English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12145/12927 (94%)
Visitors : 908213      Online Users : 952
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14423


    Title: Diabetes, hypertension, and the risk of dementia
    Authors: Yen, FS;Wei, JC;Yip, HT;Hwu, CM;Hsu, CC
    Contributors: Institute of Population Health Sciences;National Center for Geriatrics and Welfare Research
    Abstract: BACKGROUND: Type 2 diabetes (T2D) and hypertension (HTN) are well-known modifiable risk factors for dementia, but their intricate attributes accounting for dementia development has not been clearly delineated. OBJECTIVE: We conducted this study to investigate and compare the effects of T2D and HTN on dementia risk. METHODS: We screened data of matched pairs of patients with T2D or HTN between January 1, 2000 and December 31, 2017 from Taiwan's National Health Insurance Research Database. Fine and Gray's subdistribution hazard models were used for calculating the risk of dementia. RESULTS: Patients with T2D and subsequent HTN were associated with significantly higher risks of all-cause dementia (aHR 1.51, 95% CI 1.25-1.83) and vascular dementia (aHR 2.30, 95% CI 1.71-3.13) compared with those without subsequent HTN. Patients with HTN and subsequent T2D were associated with significantly higher risks of all-cause dementia (aHR 1.15, 95% CI 1.08-1.21), vascular dementia (aHR 1.25, 95% CI 1.62-1.34), and other dementia (aHR 1.31, 95% CI 1.03-1.66) compared with those without subsequent HTN. The subgroups of male and female patients, age of 50-69 and 70-90 years with subsequent comorbidity were associated with significantly higher risks of all-cause dementia and vascular dementia than those without subsequent comorbidity. CONCLUSION: This nationwide cohort study demonstrated that patients with T2D and subsequent HTN had association with higher risks of all-cause dementia and vascular dementia, and those with HTN and subsequent T2D were associated with higher risks of all-cause dementia, vascular dementia, and other dementia.
    Date: 2022-08-30
    Relation: Journal of Alzheimer's Disease. 2022 Aug 30;89(1):323-333.
    Link to: http://dx.doi.org/10.3233/jad-220207
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1387-2877&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000850436900026
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85137153580
    Appears in Collections:[許志成] 期刊論文
    [許志成] 期刊論文

    Files in This Item:

    File Description SizeFormat
    PUB35871336.pdf267KbAdobe PDF139View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback