國家衛生研究院 NHRI:Item 3990099045/1440
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    题名: Glutamate decarboxylase genes and alcoholism in Han Taiwanese men
    作者: Loh, EW;Lane, HY;Chen, CH;Chang, PS;Ku, LW;Wang, KHT;Cheng, ATA
    贡献者: Division of Mental Health and Substance Abuse Research
    摘要: Objective: Glutamate decarboxylase (GAD), the rate-limiting enzyme in the synthesis of gamma-aminobutyric acid (GABA), may be involved in the development of alcoholism. This study examined the possible roles of the genes that code for 2 forms of GAD (GAD1 and GAD2) in the development of alcoholism. Method: An association study was conducted among 140 male alcoholic subjects meeting the DSM-III-R criteria for alcohol dependence and 146 controls recruited from the Han Taiwanese in community and clinical settings. Psychiatric assessment of drinking conditions was conducted using a Chinese version of the Schedules for Clinical Assessment in Neuropsychiatry. The SHEsis and Haploview programs were used in statistical analyses. Results: Nine single-nucleotide polymorphisms (SNPs) at the GAD1 gene were valid for further statistics. Between alcoholic subjects and controls, significant differences were found in genotype distributions of SNP1 (p=0.000), SNP2 (p=0.015), SNP4 (p=0.015), SNP5 (p=0.031), SNP6 (p=0.012), and SNP8 (p=0.004) and in allele distributions of SNP1 (p=0.001), SNP2 (p=0.009), and SNP8 (p=0.009). Permutation tests of SNP1, SNP2, and SNP8 demonstrated significant differences in allele frequencies but not in 2 major haplotype blocks. Three valid SNPs at the GAD2 gene demonstrated no associations with alcoholism. Further permutation tests in the only 1 haplotype block or individual SNPs demonstrated no significant differences. Conclusions: This is the first report indicating a possible significant role of the GAD1 gene in the development of alcohol dependence and/or the course of alcohol withdrawal and outcome of alcoholism.
    关键词: Substance Abuse
    日期: 2006-11
    關聯: Alcoholism: Clinical and Experimental Research. 2006 Nov;30(11):1817-1823.
    Link to: http://dx.doi.org/10.1111/j.1530-0277.2006.00218.x
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000241510400002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33750290923
    显示于类别:[羅爾維(2004-2012)] 期刊論文

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