國家衛生研究院 NHRI:Item 3990099045/14401
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14401


    Title: The synergistic inhibition of coronavirus replication and induced cytokine production by ciclesonide and the tylophorine-based compound dbq33b
    Authors: Lee, YZ;Hsu, HY;Yang, CW;Lin, YL;Chang, SY;Yang, RB;Liang, JJ;Chao, TL;Liao, CC;Kao, HC;Chang, JY;Sytwu, HK;Chen, CT;Lee, SJ
    Contributors: Institute of Biotechnology and Pharmaceutical Research;National Institute of Infectious Diseases and Vaccinology
    Abstract: Ciclesonide is an inhaled corticosteroid used to treat asthma and has been repurposed as a treatment for mildly ill COVID-19 patients, but its precise mechanism of action is unclear. Herein, we report that ciclesonide blocks the coronavirus-induced production of the cytokines IL-6, IL-8, and MCP-1 by increasing IκBα protein levels and significantly decreasing p65 nuclear translocation. Furthermore, we found that the combination of ciclesonide and dbq33b, a potent tylophorine-based coronavirus inhibitor that affects coronavirus-induced NF-κB activation a little, additively and synergistically decreased coronavirus-induced IL-6, IL-8, and MCP-1 cytokine levels, and synergistically inhibited the replication of both HCoV-OC43 and SARS-CoV-2. Collectively, the combination of ciclesonide and dbq33b merits consideration as a treatment for COVID-19 patients who may otherwise be overwhelmed by high viral loads and an NF-κB-mediated cytokine storm.
    Date: 2022-07-21
    Relation: Pharmaceutics. 2022 Jul 21;14(7):Article number 1511.
    Link to: http://dx.doi.org/10.3390/pharmaceutics14071511
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1999-4923&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000832463200001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85136376382
    Appears in Collections:[Shiow-Ju Lee] Periodical Articles
    [Chiung-Tong Chen] Periodical Articles
    [Jang-Yang Chang] Periodical Articles
    [Huey-Kang Sytwu] Periodical Articles

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