國家衛生研究院 NHRI:Item 3990099045/1439
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1439


    Title: Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations
    Authors: Nakamura, K;Chen, CK;Sekine, Y;Iwata, Y;Anitha, A;Loh, EW;Takei, N;Suzuki, A;Kawai, M;Takebayashi, K;Suzuki, K;Minabe, Y;Tsuchiya, K;Yamada, K;Iyo, M;Ozaki, N;Inada, T;Iwata, N;Harano, M;Komiyama, T;Yamada, M;Sora, I;Ujike, H;Ball, DM;Yoshikawa, T;Lin, SK;Mori, N
    Contributors: Division of Mental Health and Substance Abuse Research
    Abstract: SOD2 (superoxide dismutase 2) plays a crucial role in protecting the cells against damage caused by free radicals, by catalyzing their detoxification. On the other hand, cell damage caused by free radical generation following methamphetamine administration has been postulated as one of the possible pathophysiological mechanisms for methamphetamine psychosis. Hence, we investigated the association of SOD2 polymorphisms with the development of methamphetamine psychosis, in two independent populations of Japan and Taiwan. We recruited 116 patients with methamphetamine psychosis and 189 controls in Japan, and 135 patients with methamphetamine psychosis and 204 controls in Taiwan. The methamphetamine group was divided into two clinical subtypes: a transient type of psychosis (i.e., good prognosis) and a prolonged type of psychosis (i.e., poor prognosis), according to the course of the manifestation of psychosis. With reference to the genotypic and allelic frequencies of Ala/Val functional polymorphism in exon 2, we found significant differences between individuals with prolonged methamphetamine psychosis and control samples from Japan and Taiwan in the genotypic (P value 0.014 and 0.016, respectively) and in the allelic (P value 0.004 and 0.047, respectively) frequencies. Our results suggest that Ala/Val polymorphism of the SOD2 gene could be associated with the risk of developing methamphetamine psychosis.
    Keywords: Genetics & Heredity
    Date: 2006-09
    Relation: Human Genetics. 2006 Sep;120(2):243-252.
    Link to: http://dx.doi.org/10.1007/s00439-006-0189-y
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0340-6717&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000239730300011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33746995982
    Appears in Collections:[El-Wui Loh(2004-2012)] Periodical Articles

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