國家衛生研究院 NHRI:Item 3990099045/14399
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    題名: Development of a cross-conjugated vinylogous [4+2] anionic annulation and application to the total synthesis of natural antibiotic (±)-ABX
    作者: Huang, JK;Shia, KS
    貢獻者: Institute of Biotechnology and Pharmaceutical Research
    摘要: The cross-conjugated vinylogous [4+2] anionic annulation has been newly developed, the cascade process of which has a high preference for regiochemical control and chemoselectivity, giving rise to exclusively Michael-type adducts in moderate to high yields (up to 94%, 35 examples). By making use of this approach as a key operation, the first total synthesis of natural antibiotic ABX, in racemic form, has been successfully achieved in a concise 7-step sequence with an overall yield of about 20%.
    日期: 2020-01-16
    關聯: Advanced Materials. 2020 Jan 16;132(16):6602-6607.
    Link to: http://dx.doi.org/10.1002/ANGE.201914657
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0935-9648&DestApp=IC2JCR
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85134875624
    顯示於類別:[夏克山] 期刊論文

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