國家衛生研究院 NHRI:Item 3990099045/1437
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    题名: HTF9C gene of 22q11.21 region associates with schizophrenia having deficit-sustained attention
    作者: Liu, YL;Fann, CSJ;Liu, CM;Chang, CC;Yang, WC;Wu, JY;Hung, SL;Chan, HY;Chen, JJ;Hsieh, MH;Hwang, TJ;Faraone, SV;Tsuang, MT;Chen, WJ;Hwu, HG
    贡献者: Division of Mental Health and Substance Abuse Research
    摘要: Objective A region at chromosome 22q11.21 has been reported to potentially harbor a candidate gene for schizophrenia, ZDHHC8 (zinc finger, DHHC domain containing 8; also annotated as KIAA1292) in a number of studies. This finding has been replicated in Han Chinese, but not in other ethnicity-specific studies. For further support from within the Han Chinese ethnic group, we selected two single nucleotide polymorphisms (SNP) located at the distal 5'-end (rs1633445; intron 10 of Hpall tiny fragments locus 9C, HTF9C) and the intron 4 (rs175174) of ZDHHC8 gene to test if these were associated with schizophrenia in a study sample of Taiwan. Methods A total of 218 schizophrenia families with at least two affected siblings participated in this study. These two SNPs were genotyped using matrix-assisted laser desorption/localization ionization time of flight (MALDI-TOF) mass spectrometry. Results Significant associations with schizophrenia were not shown from these two SNPs. After stratifying schizophrenia according to the deficit and the nondeficit of sustained attention assessed by the Continuous Performance Test, the rs1633445 showed significant association with schizophrenia in the presence of a deficit in sustained attention (P<0.04). Conclusion SNP rs1633445 of the HTF9C gene may be associated with a deficit in sustained attention within schizophrenia, in a Taiwanese cohort. The deficit of sustained attention may be an endophenotype of schizophrenia, and warrants further study.
    关键词: Genetics & Heredity;Neurosciences
    日期: 2007-12
    關聯: Psychiatric Genetics. 2007 Dec;17(6):333-338.
    Link to: http://dx.doi.org/10.1097/YPG.0b013e328133f321
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0955-8829&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000250695400003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=38749104331
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