國家衛生研究院 NHRI:Item 3990099045/14373
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    題名: Manipulation of surface hydration states by tuning the oligo(ethylene glycol) moieties on PEDOT to achieve platelet-resistant bioelectrode applications
    作者: Huang, JJ;Lin, CH;Tanaka, Y;Yamamoto, A;Luo, SC;Tanaka, M
    貢獻者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Poly(3,4-ethylenedioxythiophene) (PEDOT) and its derivatives have demonstrated potential in the development of bioelectrodes because of their superior conductivity. However, developing reliable implanted bioelectrodes requires improvements in biocompatibility and the prevention of nonspecific adhesion. In this study, a six ethylene glycol (EG)-functionalized EDOTs with three different EG lengths (tri-EG, tetra-EG, and hexa-EG) and two types of end groups, hydroxyl (−OH) and methoxy (−OCH3) is synthesized and systematically investigated. By coating them on gold electrodes using electropolymerization, the surface and electrochemical properties of these functionalized PEDOT-coated electrodes are investigated. Although PEDOT with −OH groups on the surface is more hydrophilic, those with −OCH3 groups on the surface exhibit higher electrochemical activity and lower impedance. The increase in EG units and −OCH3 groups on the surface effectively reduces the adhesion between the PEDOT and atomic force microscopy tips. PEDOT with longer EG lengths and −OCH3 groups exhibits relatively few adhered platelets, and the results of the analysis of hydrated states through differential scanning calorimetry are consistent with those of the platelet adhesion test. This study suggests that a tetra(EG)-functionalized PEDOT with −OCH3 groups on the surface is a promising coating for implanted bioelectrode applications.
    日期: 2022-09-23
    關聯: Advanced Materials Interfaces. 2022 Sep 23;Article number 2200707.
    Link to: http://dx.doi.org/10.1002/admi.202200707
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2196-7350&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000814544900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85132444261
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