國家衛生研究院 NHRI:Item 3990099045/14347
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 906484      在线人数 : 988
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/14347


    题名: Intravitreal bevacizumab is associated with prolonged ventilatory support in preterm infants with bronchopulmonary dysplasia
    作者: Huang, CY;Huang, HC;Chen, MH;Lai, TT;Chou, HC;Chen, CY;Yen, TA;Cardoso, WV;Tsao, PN
    贡献者: Institute of Population Health Sciences
    摘要: BACKGROUND: Intravitreal bevacizumab (IVB), an anti-vascular endothelial growth factor (anti-VEGF) antibody, is a widely adopted treatment for retinopathy of prematurity (ROP). Although animal studies have demonstrated that IVB inhibits alveologenesis in neonatal rat lung, the clinical influence of IVB on respiratory outcomes has never been studied. RESEARCH QUESTION: Would intravitreal bevacizumab affect the respiratory outcome in preterm infants with bronchopulmonary dysplasia? STUDY DESIGN AND METHODS: We retrospectively assessed very low birth weight (VLBW) preterm infants admitted to our neonatal intensive care unit between January 2016 and June 2021. Furthermore, we evaluated the short-term respiratory outcomes after IVB therapy in VLBW preterm infants requiring ventilatory support at a postmenstrual age (PMA) of 36 weeks. RESULTS: One hundred and seventy-four VLBW preterm infants with bronchopulmonary dysplasia were recruited. There were 88 infants with ROP onset before ventilator-free and 78 infants with the most severe ROP diagnosed before ventilator-free. Among them, 32 were diagnosed with type-1 ROP and received IVB treatment. After adjusting for gestational age, birth bodyweight, and baseline respiratory status, we discovered that IVB is significantly associated with prolonged ventilatory support and a lower likelihood of ventilator-free (HR = 0.53, P = 0.03). INTERPRETATION: IVB may have a short-term respiratory adverse effect in patients requiring ventilatory support at PMA of 36 weeks. Therefore, long-term follow up for respiratory outcomes may be considered in VLBW infants with IVB treatment.
    日期: 2022-12
    關聯: Chest. 2022 Dec;162(6):1328-1337.
    Link to: http://dx.doi.org/10.1016/j.chest.2022.06.017
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0012-3692&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000904987800017
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85139022371
    显示于类别:[陳美惠] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    PUB35753385.pdf734KbAdobe PDF234检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈