國家衛生研究院 NHRI:Item 3990099045/1430
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1430


    Title: Association study of polymorphisms in the mitochondrial aspartate/glutamate carrier SLC25A12 (aralar) gene with schizophrenia
    Authors: Hong, CJ;Liou, YJ;Liao, DL;Hou, SJ;Yen, FC;Tsai, SJ
    Contributors: Division of Mental Health and Substance Abuse Research
    Abstract: Aralar is a mitochondrial calcium-regulated aspartate-glutamate carrier mainly distributed in brain and skeletal muscle, and involved in the transport of aspartate from mitochondria to the cytosol of a cell. Studies have shown that the brain N-acetyl aspartate (NAA) levels are greatly decreased in aralar-deficient mice, suggesting that aralar plays an important role in the synthesis of NAA in neuronal cells. Since magnetic resonance spectroscopy studies have revealed consistently reduced NAA levels in various brain regions of schizophrenic patients and their unaffected relatives, genes that affect aralar levels or NAA metabolism in the brain may be implicated in the pathogenesis of schizophrenia. Aralar is encoded by the SLC25A12 gene. In the past this gene has been found to be associated with susceptibility to autism; in this study we tested the hypothesis that SLC25A12 genetic variants confer susceptibility to schizophrenia. Six SLC25A12 polymorphisms were studied in a sample population of 253 people with schizophrenia and 216 normal controls. Significant linkage disequilibrium was obtained among the six polymorphisms. However, neither single marker nor haplotype analysis revealed an association between variants at the SLC25A12 locus and schizophrenia, suggesting that it is unlikely that the SLC25A12 polymorphisms investigated play a substantial role in conferring susceptibility to schizophrenia in the Chinese population. Further studies with SLC25A12 variants relating to brain NAA levels in patients with schizophrenia are suggested. (c) 2007 Elsevier Inc. All rights reserved.
    Keywords: Clinical Neurology;Neurosciences;Pharmacology & Pharmacy;Psychiatry
    Date: 2007-10-01
    Relation: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2007 Oct;31(7):1510-1513.
    Link to: http://dx.doi.org/10.1016/j.pnpbp.2007.07.010
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0278-5846&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000249679100025
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34548137728
    Appears in Collections:[Ding-Lieh Liao(2005-2008)] Periodical Articles

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