國家衛生研究院 NHRI:Item 3990099045/14251
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    题名: Protection-free strategy for the synthesis of boro-depsipeptides in aqueous media under microwave-assisted conditions
    作者: Qiu, SB;Liu, PY;Wang, BC;Chen, PR;Xiao, JH;Hsu, TY;Pan, KL;Lai, ZY;Chen, YW;Chen, YC;Chen, JK;Pan, PS
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: In this report, 19 boron-containing depsipeptides were synthesized via microwave-assisted Passerini three-component reaction (P-3CR) in an aqueous environment. The linker-free DAHMI fluorescent tagging approach was used on selected boron-containing compounds to study the relationship between their structures and their level of cellular uptake of HEK293 cells. The biological data retrieved from the DAHMI experiments indicated that while the structures of tested compounds may be highly similar, their bio-distribution profile could be vastly distinctive. The reported optimized one-pot synthetic strategy along the linker-free in vitro testing protocol could provide an efficient platform to accelerate the development of boron-containing drugs.
    日期: 2022-04-04
    關聯: Molecules. 2022 Apr 4;27(7):Article number 2325.
    Link to: http://dx.doi.org/10.3390/molecules27072325
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1420-3049&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000782033900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85128040889
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