國家衛生研究院 NHRI:Item 3990099045/14248

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14248

Title:	Investigating a curcumin-Loaded PLGA-PEG-PLGA thermo-sensitive hydrogel for the prevention of Alzheimer’s disease
Authors:	Lin, YW;Fang, CH;Yang, CY;Liang, YJ;Lin, FH
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	In Alzheimer’s disease (AD), the most common cause of dementia, patients generally forget to take pills or skip medication due to side effects, affecting the treatment efficacy. In this study, we combined a poly(lactic-co-glycolic acid), (PLGA)-poly(ethylene glycol), and (PEG)-PLGA thermo-sensitive hydrogel with curcumin (PGC) to deliver an intramuscular injection that could continuously release curcumin and maintain it at a constant level in blood to prevent AD development or progression. We evaluated the drug release profile and cytotoxicity of PGC and its effects on AD pathology through in vitro and in vivo studies and on cognitive function through an aluminum-chloride-induced AD rat model. In the in vitro study, PGC exhibited a lack of cytotoxicity, excellent anti-inflammatory and antioxidant properties, and microglial modulation. In the Morris water maze test, the PGC injection-administered AD rats presented well-focused searching behavior with the shortest swimming path and longest retention times in the quadrant where the platform was initially located. Furthermore, PGC reduced amyloid-beta aggregation and deposition and significantly increased hippocampal activity. This study demonstrated that intramuscular PGC injection can effectively prevent AD development or progression in rats without inducing toxicity; therefore, this strategy could help overcome the present challenges in AD management in humans.
Date:	2022-04-07
Relation:	Antioxidants. 2022 Apr 7;11(4):Article number 727.
Link to:	http://dx.doi.org/10.3390/antiox11040727
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2076-3921&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000785152700001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85127669257
Appears in Collections:	[Feng-Huei Lin] Periodical Articles

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