| Abstract: | Introduction: The current review aims to summarize and interpret updated epidemiologic evidence on the relationship between occupational chemical exposures and adverse reproductive outcomes among workers during 2006-2021. Materials and Methods: Relevant studies published during 2006-2021 were identified through the search of PubMed database using "Reproduction"[MeSH Terms]) AND ("occupation*"OR "Occupational Exposure"[MeSH Terms] as keywords. Only human epidemiologic studies that address occupational chemical exposures were included. Results: Among 5,441 searched articles, 212 articles were included. The importance of major findings of the abovementioned reviews, including metals (52 articles, including lead, mercury, nickel, manganese, cadmium, aluminum, selenium, and metal welding fumes), organic solvents (26 articles, including methanol, formaldehyde, aromatic hydrocarbon solvents, toluene, and cleaning agents), pesticides (56 articles), and medications (9 articles, including antineoplastics and anesthetics), did not diminish during the last 15 years. In addition, evidence for emerging chemical agents was also noted, including bisphenol-A and phthalate (14 articles), PFAS (11 articles), PAH (8 articles), inorganic and organic particles (8 articles), disinfectants (5 articles), and VOC (4 articles). Conclusions: Although there is only limited epidemiological evidence with mixed results, preventive interventions are suggested for precautious protection of reproductive health of both women and men, and more evidence is needed to conclude. |
