國家衛生研究院 NHRI:Item 3990099045/14111
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    题名: Enhancing CISD2 expression to retard liver aging
    作者: Huang, YL;Shen, ZQ;Tsai, TF
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: Liver is a pivotal metabolic organ that is responsible for xenobiotic detoxification, protein synthesis, bile production and energetic balance. Aging of the liver manifests as multiple functional and structural alterations [1]. Cisd2, the second member of the CDGSH iron-sulfur domain-containing protein family in mammals, has been shown to serve as an anti-aging protein that can modulate longevity and maintain cellular homeostasis [2]. Here our laboratory highlights a key factor underlying liver dysfunction during aging, which is a reduction in Cisd2 expression [3]. In a series of mouse studies, the robust protective effects of Cisd2 on age-associated or diet-induced liver damage were demonstrated. In agreement with the above, a persistently high level of Cisd2 appears to slow down the aging rate of liver in mice and the results are likely to be similar in humans (summarized in Figure 1A).
    日期: 2022-02-28
    關聯: Aging. 2022 Feb 28;14(4):1594-1596.
    Link to: http://dx.doi.org/10.18632/aging.203929
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1945-4589&DestApp=IC2JCR
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