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    Title: 作为对抗肠病毒感染之免疫原的病毒颗粒及其制造
    Authors: Chong, PC-S;Liu, CC;Lin, HY;Chow, YH
    Contributors: National Institute of Infectious Diseases and Vaccinology
    Abstract: 本发明关于一种作为对抗肠病毒感染之免疫原的病毒颗粒及其制造方法。具体而言,本发明特征在于使用人胚肾293(HEK293)细胞以制造肠病毒A型之病毒颗粒,具体而言是指克沙奇病毒A6(CVA6)颗粒、或克沙奇病毒A10(CVA10)颗粒、或两者皆包含、及其他可选之肠病毒A型病毒颗粒,像是克沙奇病毒A16(CVA16)、及/或肠病毒A71(EV71)。令人惊讶的是,于HEK293细胞中所能收获之病毒颗粒相当高,且可有效诱发对抗肠病毒感染之免疫反应,特别是对CVA6及CVA10。本发明亦关于一种对抗肠病毒感染之人用免疫组合物,包含如本文所述之病毒颗粒,以及一种预防肠病毒感染或其所造成疾病之方法,具体而言是指手足口病(Hand‑Food‑Mouth disease;HFMD),该方法是藉由施予该免疫组合物给有需要之个体。
    Date: 2021-01-26
    Relation: CN106661102B/2021-01-26
    Link to: https://worldwide.espacenet.com/patent/search/family/054697781/publication/CN106661102B?q=CN106661102B
    Appears in Collections:[劉家齊] 專利
    [莊再成] 專利
    [周彥宏] 報告

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