國家衛生研究院 NHRI:Item 3990099045/1402
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    题名: Placenta-derived multipotent cells differentiate into neuronal and glial cells in vitro
    作者: Yen, BL;Chien, CC;Chen, YC;Chen, JT;Huang, JS;Lee, K;Huang, HI
    贡献者: Stem Cell Research Center
    摘要: Stem cells have great potential for clinical application because of their self-renewal property and ability to differentiate into many types of cells, but because there are ethical and biological limitations with current sources of stem cells, the search continues for more suitable sources of multipotent cells. We have reported previously on a population of multipotent cells isolated from the human term placenta, an ethically unproblematic and easily available source of tissue. These placenta-derived multipotent cells (PDMCs) can differentiate into lineages of mesenchymal tissues, including osteoblasts and adipocytes, as well as non-mesenchymal tissue of neuron-like cells. We further examined the ability of PDMCs to differentiate into all 3 types of neural cells-neurons, astrocytes, and oligodendrocytes-under various induction conditions, including retinoic acid (RA), 1-methyl-3-isobutylxanthine (IBMX), and co-culture with neonatal rat brain cells. PDMCs exhibited outgrowth of processes and the expression of neuron-specific molecules such as neuron-specific enolase upon induction. Co-culture with neonatal rat brain cells also induced neural differentiation. Our results indicate that PDMCs can be differentiated into neural cell types of the human nervous system upon exposure to RA, IBMX, or primary rat brain cells.
    关键词: Biotechnology & Applied Microbiology;Cell Biology
    日期: 2008-01
    關聯: Tissue Engineering Part A. 2008 Jan;14(1):9-17.
    Link to: http://dx.doi.org/10.1089/ten.a.2006.0352
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1937-3341&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000253960900002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=38349188450
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