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http://ir.nhri.org.tw/handle/3990099045/13988
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| Title: | Low-density lipoprotein cholesterol and mortality in patients with intracerebral hemorrhage in Taiwan |
| Authors: | Wen, CP;Lee, YC;Sun, YT;Huang, CY;Tsai, CH;Chen, PL;Chang, WL;Yeh, PY;Wei, CY;Tsai, MJ;Sun, Y;Lin, CH;Lee, JT;Lai, TC;Lien, LM;Lin, MC;Lin, CL;Lee, JH;Wang, HK;Hsu, CY;Investigators, Taiwan Stroke Registry |
| Contributors: | Institute of Population Health Sciences |
| Abstract: | Objective: Lower serum low-density lipoprotein cholesterol (LDL-C) levels are associated with increased intracerebral hemorrhage (ICH) risk. However, reverse causality and residual confounding has not attracted public attention. Therefore, we assessed whether people with LDL-C have increased risk of mortality adjusting for potential confounders using two large Taiwan cohorts.Methods: The Mei-Jhao (MJ) cohort has 414,372 adults participating in a medical screening program with 378 ICH deaths within 15 years of follow-up (1994-2008). Cox proportional hazards regressions estimated hazard death ratios according to LDL-C levels. We identified 4,606 ICH patients from the Taiwan Stroke Registry (TSR) and analyzed the impact of LDL-C on 3-month mortality.Results: Low cholesterol (LDL-C <100 mg/dL), found in 1/4 of the MJ cohort, was highly prevalent (36%) among young adults (age 20-39). There was a graded relationship between cholesterol and mortality for ICH [Hazard ratio, 1.56; 95% confidence interval (CI), 1.13-2.16]. Compared with patients with an LDL-C of 110-129 mg/dL in TSR, the risk for mortality was 1.84 (95% CI, 1.28-2.63) with an LDL-C of Conclusion: Lower serum LDL-C level independently predicts higher mortality after acute ICH. While its causative role may vary, low cholesterol may pose potential harms in Taiwan. |
| Date: | 2022-01-17 |
| Relation: | Frontiers in Neurology. 2022 Jan 17;12:Article number 793471. |
| Link to: | http://dx.doi.org/10.3389/fneur.2021.793471 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1664-2295&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000749861000001 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85123918675 |
| Appears in Collections: | [溫啟邦(2001-2010)] 期刊論文
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| ISI000749861000001.pdf | | 560Kb | Adobe PDF | 167 | View/Open |
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