國家衛生研究院 NHRI:Item 3990099045/13986
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    题名: Genetic polymorphisms of MnSOD modify the impacts of environmental melamine on oxidative stress and early kidney injury in calcium urolithiasis patients
    作者: Liu, CC;Wu, CF;Lee, YC;Huang, TY;Huang, ST;Wang, HS;Jhan, JH;Huang, SP;Li, CC;Juan, YS;Hsieh, TJ;Tsai, YC;Chen, CC;Wu, MT
    贡献者: Institute of Population Health Sciences
    摘要: Environmental melamine exposure increases the risks of oxidative stress and early kidney injury. Manganese superoxide dismutase (MnSOD), glutathione peroxidase, and catalase can protect the kidneys against oxidative stress and maintain normal function. We evaluated whether their single-nucleotide polymorphisms (SNPs) could modify melamine's effects. A total of 302 patients diagnosed with calcium urolithiasis were enrolled. All patients provided one-spot overnight urine samples to measure their melamine levels, urinary biomarkers of oxidative stress and renal tubular injury. Median values were used to dichotomize levels into high and low. Subjects carrying the T allele of rs4880 and high melamine levels had 3.60 times greater risk of high malondialdehyde levels than those carrying the C allele of rs4880 and low melamine levels after adjustment. Subjects carrying the G allele of rs5746136 and high melamine levels had 1.73 times greater risk of high N-Acetyl-beta-d-glucosaminidase levels than those carrying the A allele of rs5746136 and low melamine levels. In conclusion, the SNPs of MnSOD, rs4880 and rs5746136, influence the risk of oxidative stress and renal tubular injury, respectively, in calcium urolithiasis patients. In the context of high urinary melamine levels, their effects on oxidative stress and renal tubular injury were further increased.
    日期: 2022-01
    關聯: Antioxidants. 2022 Jan;11:Article number 152.
    Link to: http://dx.doi.org/10.3390/antiox11010152
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2076-3921&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000747269500001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85122898801
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