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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13972


    Title: Mapping the human gut mycobiome in middle-aged and elderly adults: Multiomics insights and implications for host metabolic health
    Authors: Shuai, ML;Fu, YQ;Zhong, HL;Gou, WL;Jiang, ZL;Liang, YH;Miao, ZL;Xu, JJ;Huynh, T;Wahlqvist, ML;Chen, YM;Zheng, JS
    Contributors: Institute of Population Health Sciences
    Abstract: Objective The human gut fungal community, known as the mycobiome, plays a fundamental role in the gut ecosystem and health. Here we aimed to investigate the determinants and long-term stability of gut mycobiome among middle-aged and elderly adults. We further explored the interplay between gut fungi and bacteria on metabolic health. Design The present study included 1244 participants from the Guangzhou Nutrition and Health Study. We characterised the long-term stability and determinants of the human gut mycobiome, especially long-term habitual dietary consumption. The comprehensive multiomics analyses were performed to investigate the ecological links between gut bacteria, fungi and faecal metabolome. Finally, we examined whether the interaction between gut bacteria and fungi could modulate the metabolic risk. Results The gut fungal composition was temporally stable and mainly determined by age, long-term habitual diet and host physiological states. Specifically, compared with middle-aged individuals, Blastobotrys and Agaricomycetes spp were depleted, while Malassezia was enriched in the elderly. Dairy consumption was positively associated with Saccharomyces but inversely associated with Candida. Notably, Saccharomycetales spp interacted with gut bacterial diversity to influence insulin resistance. Bidirectional mediation analyses indicated that bacterial function or faecal histidine might causally mediate an impact of Pichia on blood cholesterol. Conclusion We depict the sociodemographic and dietary determinants of human gut mycobiome in middle-aged and elderly individuals, and further reveal that the gut mycobiome may be closely associated with the host metabolic health through regulating gut bacterial functions and metabolites.
    Date: 2022-09-01
    Relation: Gut. 2022 Sep 11;79(9):1812-1820.
    Link to: http://dx.doi.org/10.1136/gutjnl-2021-326298
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0017-5749&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000742093000001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85133486491
    Appears in Collections:[MARK LAWRENCE WAHLQVIST(2008-2012)] 期刊論文

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