國家衛生研究院 NHRI:Item 3990099045/13967

NHRI > National Institute of Infectious Diseases and Vaccinology > Chi-Jung Wu > Periodical Articles > Item 3990099045/13967

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13967

Title:	Clinical and microbiological characteristics of culture-positive, influenza-associated pulmonary aspergillosis: A single-center study in Southern Taiwan, 2016-2019
Authors:	Wu, CJ;Cia, CT;Wang, HC;Chen, CW;Lin, WC;Lee, JC;Chen, PS;Hsieh, CC;Li, WT;Su, PL;Liao, XM;Hsieh, MI;Choi, PC;Ko, WC
Contributors:	National Institute of Infectious Diseases and Vaccinology
Abstract:	This study delineated the characteristics of 24 (11.2%) culture-positive, influenza-associated pulmonary aspergillosis (IAPA) patients out of 215 patients with severe influenza during 2016-2019 in a medical center in southern Taiwan. Twenty (83.3%) patients did not have EORTC/MSG-defined host factors. The mean time from influenza diagnosis to Aspergillus growth was 4.4 days, and 20 (83.3%) developed IAPA within seven days after influenza diagnosis. All patients were treated in intensive care units and all but one (95.8%) received mechanical ventilation. Aspergillus tracheobronchitis was evident in 6 (31.6%) of 19 patients undergoing bronchoscopy. Positive galactomannan testing of either serum or bronchoalveolar lavage was noted in all patients. On computed tomography imaging, IAPA was characterized by peribronchial infiltrates, multiple nodules, and cavities superimposed on ground-glass opacities. Pure Aspergillus growth without bacterial co-isolation in culture was found in 17 (70.8%) patients. A. fumigatus (15, 62.5%), A. flavus (6, 25.0%), and A. terreus (4, 16.7%) were the major causative species. Three patients had mixed Aspergillus infections due to two species, and two had mixed azole-susceptible and azole-resistant A. fumigatus infection. All patients received voriconazole with an all-cause mortality of 41.6%. Of 14 survivors, the mean duration of antifungal use was 40.5 days. In conclusion, IAPA is an early and rapidly deteriorating complication following influenza that necessitates clinical vigilance and prompt diagnostic workup.
Date:	2022-01-04
Relation:	Journal of Fungi. 2022 Jan 04;8(1):Article number 49.
Link to:	http://dx.doi.org/10.3390/jof8010049
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2309-608X&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000747058300001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85122326700
Appears in Collections:	[Chi-Jung Wu] Periodical Articles

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