國家衛生研究院 NHRI:Item 3990099045/13926

NHRI > Institute of Biomedical Engineering and Nanomedicine > Feng-Huei Lin > Periodical Articles > Item 3990099045/13926

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13926

Title:	Design strategy for a hydroxide-triggered pH-responsive hydrogel as a mucoadhesive barrier to prevent metabolism disorders
Authors:	Tang, RC;Chen, TC;Lin, FH
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	Excess nutrient uptake is one of the main factors of complications related to metabolism disorders. Therefore, efforts have emerged to modulate nutrient transport in the intestine. However, current approaches are mainly invasive interventions with various side effects. Here, a pH-responsive hydrogel is formulated by acidifying the hydroxide compounds within sucralfate to allow electrostatic interactions between pectin and aluminum ions. The pH responsiveness relies on the alternation of cations and hydroxide species, providing reversible shifting from a hydrogel to a complex coacervate system. It acts as a transient physical barrier coating to inhibit intestinal absorption and changes the viscosity and barrier function in different parts of the gastrointestinal tract, showing enhanced mucoadhesive properties. The therapeutic hydrogel remarkably lowers the immediate blood glucose response by modulating nutrient contact with bowel mucosa, suggesting potential in treating diabetes. In addition, it significantly reduces weight gain, fat accumulation, and hepatic lipid deposition in rodent models. This study provides a novel strategy for fabricating pH-responsive hydrogels, which may serve as a competent candidate for metabolism disorder management.
Date:	2021-12-06
Relation:	ACS Applied Materials and Interfaces. 2021 Dec 6;13(49):58340-58351.
Link to:	http://dx.doi.org/10.1021/acsami.1c17706
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1944-8244&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000752977200010
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85121031598
Appears in Collections:	[Feng-Huei Lin] Periodical Articles

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