國家衛生研究院 NHRI:Item 3990099045/13917
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    题名: An integrated microfluidic platform for cholangiocarcinoma diagnosis from clinical bile juice samples by utilizing multiple affinity reagents
    作者: Lu, TH;Chiang, NJ;Huang, CJ;Gopinathan, P;Tu, HC;Tsai, YC;Shan, YS;Hung, SC;Lee, GB
    贡献者: National Institute of Cancer Research
    摘要: Cholangiocarcinoma (CCA) is a lethal disease owing to its difficulty to be diagnosed at early stages and lack of effective treatment. To improve the accuracy of early diagnosis of CCA, one of the promising approaches is to use CCA-specitic affinity reagents to detect CCA cells by liquid biopsy. In this study, bile juice, a body fluid close to lesions, was used as a clinical sample for CCA cell isolation and detection. Moreover, a novel microfluidic chip was designed and fabricated to detect CCA cells in the bile juice by using three types of affinity reagents. Experimental results showed that the three affinity reagents could capture CCA tumor cells in patients' bile juice (with a volume of only 3 mL) within 120 min. This microfluidic system may serve as a promising tool for detecting CCA in clinical settings.
    日期: 2020-11
    關聯: 2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (IEEE Nems 2020). 2020 Nov:261-264.
    Link to: http://dx.doi.org/10.1109/NEMS50311.2020.9265566
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000722588100044
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