國家衛生研究院 NHRI:Item 3990099045/13872
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    題名: Neuropeptide F inhibits dopamine neuron interference of long-term memory consolidation in Drosophila
    作者: Feng, KL;Weng, JY;Chen, CC;Abubaker, MB;Lin, HW;Charng, CC;Lo, CC;de Belle, JS;Tully, T;Lien, CC;Chiang, AS
    貢獻者: Institute of Molecular and Genomic Medicine
    摘要: Long-term memory (LTM) formation requires consolidation processes to overcome interfering signals that erode memory formation. Olfactory memory in Drosophila involves convergent projection neuron (PN; odor) and dopaminergic neuron (DAN; reinforcement) input to the mushroom body (MB). How post-training DAN activity in the posterior lateral protocerebrum (PPL1) continues to regulate memory consolidation remains unknown. Here we address this question using targeted transgenes in behavior and electrophysiology experiments to show that (1) persistent post-training activity of PPL1-α2α′2 and PPL1-α3 DANs interferes with aversive LTM formation; (2) neuropeptide F (NPF) signaling blocks this interference in PPL1-α2α′2 and PPL1-α3 DANs after spaced training to enable LTM formation; and (3) training-induced NPF release and neurotransmission from two upstream dorsal-anterior-lateral (DAL2) neurons are required to form LTM. Thus, NPF signals from DAL2 neurons to specific PPL1 DANs disinhibit the memory circuit, ensuring that periodic events are remembered as consolidated LTM.
    日期: 2021-12-17
    關聯: iScience. 2021 Dec 17;24(12):Article number 103506.
    Link to: http://dx.doi.org/10.1016/j.isci.2021.103506
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2589-0042&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000740243400004
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85120851455
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