國家衛生研究院 NHRI:Item 3990099045/13863
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    题名: Extracellular vesicles of adipose‐derived stem cells promote the healing of traumatized achilles tendons
    作者: Chen, SH;Chen, ZY;Lin, YH;Chen, SH;Chou, PY;Kao, HK;Lin, FH
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Healing of ruptured tendons remains a clinical challenge because of its slow progress and relatively weak mechanical force at an early stage. Extracellular vesicles (EVs) derived from mesen-chymal stem cells (MSCs) have therapeutic potential for tissue regeneration. In this study, we isolated EVs from adipose‐derived stem cells (ADSCs) and evaluated their ability to promote tendon regeneration. Our results indicated that ADSC‐EVs significantly enhanced the proliferation and migration of tenocytes in vitro. To further study the roles of ADSC‐EVs in tendon regeneration, ADSC‐ EVs were used in Achilles tendon repair in rabbits. The mechanical strength, histology, and protein expression in the injured tendon tissues significantly improved 4 weeks after ADSC‐EV treatment. Decorin and biglycan were significantly upregulated in comparison to the untreated controls. In summary, ADSC‐EVs stimulated the proliferation and migration of tenocytes and improved the mechanical strength of repaired tendons, suggesting that ADSC‐EV treatment is a potential highly potent therapeutic strategy for tendon injuries.
    日期: 2021-11-16
    關聯: International Journal of Molecular Sciences. 2021 Nov 16;22(22):Article number 12373.
    Link to: http://dx.doi.org/10.3390/ijms222212373
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000724425700001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85118988301
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