國家衛生研究院 NHRI:Item 3990099045/13833
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    题名: Genotypic diversity of ciprofloxacin nonsusceptibility and its relationship with minimum inhibitory concentrations in nontyphoidal salmonella clinical isolates in Taiwan
    作者: Fang, SB;Lauderdale, TLY;Huang, CH;Chang, PR;Wang, YH;Shigemura, K;Lin, YH;Chang, WC;Wang, KC;Huang, TW;Chang, YC
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: This study analyzed the genetic diversity of ciprofloxacin (CIP) nonsusceptibility and the relationship between two major mechanisms and minimum inhibitory concentrations (MICs) of CIP in nontyphoidal Salmonella (NTS). Chromosomal mutations in quinolone resistance-determining regions (QRDRs) and plasmid-mediated quinolone resistance (PMQR) genes were searched from ResFinder, ARG-ANNOT, and PubMed for designing the sequencing regions in gyrA, gyrB, parC, and parE, and the 13 polymerase chain reactions for PMQR genes. We found that QRDR mutations were detected in gyrA (82.1%), parC (59.0%), and parE (20.5%) but not in gyrB among the 39 isolates. Five of the 13 PMQR genes were identified, including oqxA (28.2%), oqxB (28.2%), qnrS (18.0%), aac(6′ )-Ib-cr (10.3%), and qnrB (5.1%), which correlated with the MICs of CIP within 0.25–2 µg/mL, and it was found that oxqAB contributed more than qnr genes to increase the MICs. All the isolates contained either QRDR mutations (53.8%), PMQR genes (15.4%), or both (30.8%). QRDR mutations (84.6%) were more commonly detected than PMQR genes (46.2%). QRDR mutation numbers were significantly associated with MICs (p < 0.001). Double mutations in gyrA and parC determined high CIP resistance (MICs ≥ 4 µg/mL). PMQR genes contributed to intermediate to low CIP resistance (MICs 0.25–2 µg/mL), thus providing insights into mechanisms underlying CIP resistance.
    日期: 2021-11-11
    關聯: Antibiotics. 2021 Nov 11;10(11):Article number 1383.
    Link to: http://dx.doi.org/10.3390/antibiotics10111383
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2079-6382&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000724966800001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85119601209
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