國家衛生研究院 NHRI:Item 3990099045/13828
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13828


    Title: Identification of DNA damage repair-associated prognostic biomarkers for prostate cancer using transcriptomic data analysis
    Authors: Teng, PC;Huang, SP;Liu, CH;Lin, TY;Cho, YC;Lai, YL;Wang, SC;Yeh, HC;Chuu, CP;Chen, DN;Cheng, WC;Li, CY
    Contributors: Institute of Cellular and Systems Medicine
    Abstract: In the recent decade, the importance of DNA damage repair (DDR) and its clinical application have been firmly recognized in prostate cancer (PC). For example, olaparib was just approved in May 2020 to treat metastatic castration-resistant PC with homologous recombination repair-mutated genes; however, not all patients can benefit from olaparib, and the treatment response depends on patient-specific mutations. This highlights the need to understand the detailed DDR biology further and develop DDR-based biomarkers. In this study, we establish a four-gene panel of which the expression is significantly associated with overall survival (OS) and progression-free survival (PFS) in PC patients from the TCGA-PRAD database. This panel includes DNTT, EXO1, NEIL3, and EME2 genes. Patients with higher expression of the four identified genes have significantly worse OS and PFS. This significance also exists in a multivariate Cox regression model adjusting for age, PSA, TNM stages, and Gleason scores. Moreover, the expression of the four-gene panel is highly correlated with aggressiveness based on well-known PAM50 and PCS subtyping classifiers. Using publicly available databases, we successfully validate the four-gene panel as having the potential to serve as a prognostic and predictive biomarker for PC specifically based on DDR biology.
    Date: 2021-10-29
    Relation: International Journal of Molecular Sciences. 2021 Oct 29;22(21):Article number 11771.
    Link to: http://dx.doi.org/10.3390/ijms222111771
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000718856700001
    Appears in Collections:[Chih-Pin Chuu] Periodical Articles

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