國家衛生研究院 NHRI:Item 3990099045/13822
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    题名: Identification of a gut microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice
    作者: Chang, CS;Liao, YC;Huang, CT;Lin, CM;Cheung, CHY;Ruan, JW;Yu, WH;Tsai, YT;Lin, IJ;Huang, CH;Liou, JS;Chou, YH;Chien, HJ;Chuang, HL;Juan, HF;Huang, HC;Chan, HL;Liao, YC;Tang, SC;Su, YW;Tan, TH;Bäumler, AJ;Kao, CY
    贡献者: Immunology Research Center;Institute of Population Health Sciences
    摘要: Strengthening the gut epithelial barrier is a potential strategy for management of gut microbiota-associated illnesses. Here, we demonstrate that dual-specificity phosphatase 6 (Dusp6) knockout enhances baseline colon barrier integrity and ameliorates dextran sulfate sodium (DSS)-induced colonic injury. DUSP6 mutation in Caco-2 cells enhances the epithelial feature and increases mitochondrial oxygen consumption, accompanied by altered glucose metabolism and decreased glycolysis. We find that Dusp6-knockout mice are more resistant to DSS-induced dysbiosis, and the cohousing and fecal microbiota transplantation experiments show that the gut/fecal microbiota derived from Dusp6-knockout mice also confers protection against colitis. Further culturomics and mono-colonialization experiments show that one gut microbiota member in the genus Duncaniella confers host protection from DSS-induced injury. We identify Dusp6 deficiency as beneficial for shaping the gut microbiota eubiosis necessary to protect against gut barrier-related diseases.
    日期: 2021-11-23
    關聯: Cell Reports. 2021 Nov 23;37(8):Article number 110016.
    Link to: http://dx.doi.org/10.1016/j.celrep.2021.110016
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2211-1247&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000722754700002
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85119438955
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