國家衛生研究院 NHRI:Item 3990099045/13811
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13811


    Title: Monocytes secrete CXCL7 to promote breast cancer progression
    Authors: Wang, YH;Shen, CY;Lin, SC;Kuo, WH;Kuo, YT;Hsu, YL;Wang, WC;Lin, KT;Wang, LH
    Contributors: Institute of Molecular and Genomic Medicine
    Abstract: Certain immune cells and inflammatory cytokines are essential components in the tumor microenvironment to promote breast cancer progression. To identify key immune players in the tumor microenvironment, we applied highly invasive MDA-MB-231 breast cancer cell lines to co-culture with human monocyte THP-1 cells and identified CXCL7 by cytokine array as one of the increasingly secreted cytokines by THP-1 cells. Further investigations indicated that upon co-culturing, breast cancer cells secreted CSF1 to induce expression and release of CXCL7 from monocytes, which in turn acted on cancer cells to promote FAK activation, MMP13 expression, migration, and invasion. In a xenograft mouse model, administration of CXCL7 antibodies significantly reduced abundance of M2 macrophages in tumor microenvironment, as well as decreased tumor growth and distant metastasis. Clinical investigation further suggested that high CXCL7 expression is correlated with breast cancer progression and poor overall survival of patients. Overall, our study unveils an important immune cytokine, CXCL7, which is secreted by tumor infiltrating monocytes, to stimulate cancer cell migration, invasion, and metastasis, contributing to the promotion of breast cancer progression.
    Date: 2021-11-17
    Relation: Cell Death and Disease. 2021 Nov 17;12(12):Article number 1090.
    Link to: http://dx.doi.org/10.1038/s41419-021-04231-4
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2041-4889&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000719933900002
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85119248822
    Appears in Collections:[Lu-Hai Wang] Periodical Articles

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