國家衛生研究院 NHRI:Item 3990099045/13774
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 857635      線上人數 : 695
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/13774


    題名: Predicting early antidepressant treatment response based on multiple genetic liability
    作者: Liu, CY;Wu, CS;Hsu, CL;Kuo, PH;Lin, YF
    貢獻者: Center for Neuropsychiatric Research
    摘要: Background: Antidepressants are considered one of the first-line intervention for major depressive disorder (MDD), but treatment responses vary and are often unsatisfactory. It was reported that only 35% MDD achieve remission with initial antidepressant treatment and therefore more rigorous intervention, or different therapeutic approaches are needed to achieve better outcomes. Recent research has demonstrated that that differential antidepressant response is partly attributable to genetic polymorphism and associated with genetic liability to other mental health conditions. Methods: The current study aimed to investigate associations between multiple polygenic scores (PGS) and the early treatment response to antidepressants using data from the International SSRI Pharmacogenomics Consortium (ISPC). Specifically, we selected traits with publicly available GWAS which have been reported to predict treatment outcomes of MDD and traits that have implications in antidepressant metabolism. Because the ISPC cohorts include independent participants of European and East Asian ancestries, we applied deep learning algorithms to derive multivariable polygenic models separately. We then compare model performance and predictor differences between the ancestral groups. Results: Among all the preselected PGS, PGS for schizophrenia, diastolic blood pressure, systolic blood pressure, BMI and sleep duration were significantly associated with treatment response in participants of Asian ancestry. More PGSs significantly associated with treatment response were found participants of European ancestry. Discussion: Most of the available GWAS are derived from participants of European ancestry and therefore differences in polygenic score prediction may merely reflect different genetic architectures rather than shared disease liability. More data from different ancestral groups are needed to better understand potential mechanism underlying antidepressant responses. Findings are invaluable for treatment planning to improve patients' outcomes.
    日期: 2021-10
    關聯: European Neuropsychopharmacology. 2021 Oct;51:E159.
    Link to: http://dx.doi.org/10.1016/j.euroneuro.2021.08.116
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0924-977X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000704035500280
    顯示於類別:[林彥鋒] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000704035500280.pdf50KbAdobe PDF163檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋