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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/13746
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| Title: | Preparation and characterization of moldable demineralized bone matrix/calcium sulfate composite bone graft materials |
| Authors: | Chen, IC;Su, CY;Lai, CC;Tsou, YS;Zheng, Y;Fang, HW |
| Contributors: | NHRI Graduate Student Program;Institute of Biomedical Engineering and Nanomedicine |
| Abstract: | Demineralized bone matrix (DBM) is a decalcified allo/xenograft retaining collagen and noncollagenous proteins, which has been extensively used because of its osteoconductive and osteoinductive properties. Calcium sulfate (CaSO(4), CS) is a synthetic bone substitute used in bone healing with biocompatible, nontoxic, bioabsorbable, osteoconductive, and good mechanical characteristics. This study aims to prepare a DBM/CS composite bone graft material in a moldable putty form without compromising the peculiar properties of DBM and CS. For this purpose, firstly, porcine femur was defatted using chloroform/methanol and extracted by acid for demineralization, then freeze-dried and milled/sieved to obtain DBM powder. Secondly, the α-form and β-form of calcium sulfate hemihydrate (CaSO(4)·0.5H(2)O, CSH) were produced by heating gypsum (CaSO(4)·2H(2)O). The morphology and particle sizes of α- and β-CSH were obtained by SEM, and their chemical properties were confirmed by EDS, FTIR and XRD. Furthermore, the DBM-based graft was mixed with α- or β-CSH at a ratio of 9:1, and glycerol/4% HPMC was added as a carrier to produce a putty. DBM/CSH putty possesses a low washout rate, good mechanical strength and biocompatibility. In conclusion, we believe that the moldable DBM/CSH composite putty developed in this study could be a promising substitute for the currently available bone grafts, and might have practical application in the orthopedics field as a potential bone void filler. |
| Date: | 2021-10-04 |
| Relation: | Journal of Functional Biomaterials. 2021 Oct 4;12(4):Article number 56. |
| Link to: | http://dx.doi.org/10.3390/jfb12040056 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2079-4983&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000742714900001 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85118138606 |
| Appears in Collections: | [其他] 期刊論文
[其他] 期刊論文
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| PUB34698233.pdf | | 3220Kb | Adobe PDF | 411 | View/Open |
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