國家衛生研究院 NHRI:Item 3990099045/13743

NHRI > Institute of Biotechnology and Pharmaceutical Research > Chiung-Tong Chen > Periodical Articles > Item 3990099045/13743

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13743

Title:	Engineering nano- and microparticles as oral delivery vehicles to promote intestinal lymphatic drug transport
Authors:	Miao, YB;Lin, YJ;Chen, KH;Luo, PK;Chuang, SH;Yu, YT;Tai, HM;Chen, CT;Lin, KJ;Sung, HW
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	Targeted oral delivery of a drug via the intestinal lymphatic system (ILS) has the advantages of protecting against hepatic first-pass metabolism of the drug and improving its pharmacokinetic performance. It is also a promising route for the oral delivery of vaccines and therapeutic agents to induce mucosal immune responses and treat lymphatic diseases, respectively. This article describes the anatomical structures and physiological characteristics of the ILS, with an emphasis on enterocytes and microfold (M) cells, which are the main gateways for the transport of particulate delivery vehicles across the intestinal epithelium into the lymphatics. A comprehensive overview of recent advances in the rational engineering of particulate vehicles, along with the challenges and opportunities that they present for improving ILS drug delivery, is provided, and the mechanisms by which such vehicles target and transport through enterocytes or M cells are discussed. The use of naturally sourced materials, such as yeast microcapsules and their derived polymeric beta-glucans, as novel ILS-targeting delivery vehicles is also reviewed. Such use is the focus of an emerging field of research. Their potential use in the oral delivery of nucleic acids, such as mRNA vaccines, is proposed.
Date:	2021-10-01
Relation:	Advanced Materials. 2021 Oct 01;201:Article number 2104139.
Link to:	http://dx.doi.org/10.1002/adma.202104139
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0935-9648&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000702332200001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85117135545
Appears in Collections:	[Chiung-Tong Chen] Periodical Articles

Files in This Item:

File	Description	Size	Format
ISI000702332200001.pdf		2889Kb	Adobe PDF	229	View/Open

Loading...