國家衛生研究院 NHRI:Item 3990099045/13669
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    题名: Vav2 is required for Netrin-1 receptor-class-specific spinal motor axon guidance
    作者: Tsou, YS;Wang, CY;Chang, MY;Hsu, TI;Wu, MT;Wu, YH;Tsai, WL;Chuang, JY;Kao, TJ
    贡献者: NHRI Graduate Student Program
    摘要: Background Proper guidance of neuronal axons to their targets is required to assemble neural circuits during the development of the nervous system. However, the mechanism by which the guidance of axonal growth cones is regulated by specific intermediaries activated by receptor signaling pathways to mediate cytoskeleton dynamics is unclear. Vav protein members have been proposed to mediate this process, prompting us to investigate their role in the limb selection of the axon trajectory of spinal lateral motor column (LMC) neurons. Results We found Vav2 and Vav3 expression in LMC neurons when motor axons grew into the limb. Vav2, but not Vav3, loss-of-function perturbed LMC pathfinding, while Vav2 gain-of-function exhibited the opposite effects, demonstrating that Vav2 plays an important role in motor axon growth. Vav2 knockdown also attenuated the redirectional phenotype of LMC axons induced by Dcc, but not EphA4, in vivo and lateral LMC neurite growth preference to Netrin-1 in vitro. This study showed that Vav2 knockdown and ectopic nonphosphorylable Vav2 mutant expression abolished the Src-induced stronger growth preference of lateral LMC neurites to Netrin-1, suggesting that Vav2 is downstream of Src in this context. Conclusions Vav2 is essential for Netrin-1-regulated LMC motor axon pathfinding through Src interaction.
    日期: 2022-03
    關聯: Developmental Dynamics. 2022 Mar;251(3):444-458.
    Link to: http://dx.doi.org/10.1002/dvdy.409
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1058-8388&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000684574200001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85112369043
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