國家衛生研究院 NHRI:Item 3990099045/13655
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    题名: Dextromethorphan dampens neonatal astrocyte activation and endoplasmic reticulum stress induced by prenatal exposure to buprenorphine
    作者: Lin, CH;Tao, PL;Tsay, HJ;Chiang, YC;Chang, WT;Ho, IK;Shie, FS
    贡献者: Center for Neuropsychiatric Research
    摘要: Prenatal exposure to buprenorphine renders offspring vulnerable to cerebral impairments. In this study, our data demonstrate, for the first time, that prenatal exposure to buprenorphine escalates astrocyte activation concurrent with indications of endoplasmic reticulum (ER) stress in the hippocampi of neonates, and this can be prevented by the coadministration of dextromethorphan with buprenorphine. Furthermore, dextromethorphan can inhibit the accumulation of GPR37 in the hippocampus of newborns caused by buprenorphine and is accompanied by the proapoptotic ER stress response that involves the procaspase-3/CHOP pathway. Primary astrocyte cultures derived from the neonates of the buprenorphine group also displayed aberrant ER calcium mobilization and elevated basal levels of cyclooxygenase-2 (COX-2) at 14 days in vitro while showing sensitivity to lipopolysaccharide-activated expression of COX-2. Similarly, these long-lasting defects in the hippocampus and astrocytes were abolished by dextromethorphan. Our findings suggest that prenatal exposure to buprenorphine might instigate long-lasting effects on hippocampal and astrocytic functions. The beneficial effects of prenatal coadministration of dextromethorphan might be, at least in part, attributed to its properties in attenuating astrocyte activation and hippocampal ER stress in neonates.
    日期: 2021-07
    關聯: Behavioural Neurology. 2021 Jul;2021:Article number 6301458.
    Link to: http://dx.doi.org/10.1155/2021/6301458
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0953-4180&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000678959400001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85111599751
    显示于类别:[謝奉勳] 期刊論文
    [何英剛(2006-2011)] 期刊論文
    [陶寶綠] 期刊論文

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