國家衛生研究院 NHRI:Item 3990099045/13626
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13626


    Title: Epigenetic regulation of breast cancer stem cells contributing to carcinogenesis and therapeutic implications
    Authors: Wu, HJ;Chu, PY
    Contributors: National Institute of Cancer Research
    Abstract: Globally, breast cancer has remained the most commonly diagnosed cancer and the leading cause of cancer death among women. Breast cancer is a highly heterogeneous and phenotypically diverse group of diseases, which require different selection of treatments. Breast cancer stem cells (BCSCs), a small subset of cancer cells with stem cell-like properties, play essential roles in breast cancer progression, recurrence, metastasis, chemoresistance and treatments. Epigenetics is defined as inheritable changes in gene expression without alteration in DNA sequence. Epigenetic regulation includes DNA methylation and demethylation, as well as histone modifications. Aberrant epigenetic regulation results in carcinogenesis. In this review, the mechanism of epigenetic regulation involved in carcinogenesis, therapeutic resistance and metastasis of BCSCs will be discussed, and finally, the therapies targeting these biomarkers will be presented.
    Date: 2021-08
    Relation: International Journal of Molecular Sciences. 2021 Aug;22(15):Article number 8113.
    Link to: http://dx.doi.org/10.3390/ijms22158113
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000681938200001
    Appears in Collections:[Others] Periodical Articles

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