國家衛生研究院 NHRI:Item 3990099045/13619
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    题名: BMI1-KLF4 axis deficiency improves responses to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer[Erratum:Radiotherapy and Oncology. 2020 Aug;149:249-258.]
    其它题名: Corrigendum to: “BMI1-KLF4 axis deficiency improves responses to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer"
    作者: Hsu, YC;Luo, CW;Huang, WL;Wu, CC;Chou, CL;Chen, CI;Chang, SJ;Chai, CY;Wang, HC;Chen, TY;Li, CF;Pan, MR
    贡献者: National Institute of Cancer Research
    摘要: We would like to apply 3 corrections to our published paper [1]. The reason for the correction #1 is that Figure legend 2C should be Figure legend 2D, and Figure legend 2D should be Figure 2C. Correction #2 is that Figure 4A was misplaced with Figure 4B. Correction #3 is that there is a typo error in the Figure legend 4A. These changes do not change on the results and conclusions of our paper. We apologize for any inconvenience caused. #1Figure 2. Depletion of BMI1 increases radiosensitivity of HCT-116 cells and leads to a reduction in expression of the KLF4 gene. (A) Cells (500 cells/dish) were exposed to 2 Gy irradiation (IR), 5-fluorouracil (5-FU; 2.5 µM), or IR (2 Gy) + 5-FU (2.5 µM) for 2 weeks and clonogenic activity was evaluated. Statistical analysis was performed using one-way ANOVA. (B) Cells were treated with IR (2 Gy), 5-FU (2.5 µM), or IR (2 Gy) + 5-FU (2.5 µM) and sphere formation was evaluated 14 d later for the formation of 1st generation spheres. Second generation of spheres was measured 14 d after subculture of 1st generation spheres. The experiments were repeated three times. Scare bar, 100 μm (*p < 0.05). (C) Expression levels of KLF4 mRNA in HCT-116 and BMI1-depleted cells were determined by real time qPCR. Columns represent the mean results from PCR assays performed in triplicate and normalized to GAPDH. (*p < 0.05). (D) Indicated proteins in HCT-116 cells were determined by western blotting analysis. (E) ChIP-qPCR analysis was performed to investigate the status of H3K4m3, H3K27m3, and BMI1 in the KLF4 gene promoter. The experiments were repeated three times. (*p < 0.05). #2[Formula presented] #3Figure 4. BMI1 expression is positively correlated with KLF4 expression in rectal cancer. (A) Parental SW48 cells, BMI1 overexpressing SW48 cells, parental Caco-2 cells, and BMI1-depleted Caco-2 cells were treated with 2 Gy irradiation to study clonogenic activity. Data were calculated using paired t-test. *Indicated p < 0.05. (B) Representative images of colon tumor tissues with high and low expression of BMI1 and KLF4 in the same patients who received CCRT. Original magnification: ×200, scale bar: 100 μm. The associations between BMI1 and KLF4 and were determined by X2 analysis. The p-values are shown.
    日期: 2021-10
    關聯: Radiotherapy and Oncology. 2021 Oct;163:247-248.
    Link to: http://dx.doi.org/10.1016/j.radonc.2021.07.013
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0167-8140&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000769478400007
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85111606914
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