國家衛生研究院 NHRI:Item 3990099045/13541
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    题名: A noninvasive gut-to-brain oral drug delivery system for treating brain tumors
    作者: Miao, YB;Chen, KH;Chen, CT;Mi, WL;Lin, YJ;Chang, Y;Chiang, CS;Wang, JO;Lin, KJ;Sung, HW
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Most orally administered drugs fail to reach the intracerebral regions because of the intestinal epithelial barrier (IEB) and the blood-brain barrier (BBB), which are located between the gut and the brain. Herein, an oral prodrug delivery system that can overcome both the IEB and the BBB noninvasively is developed for treating gliomas. The prodrug is prepared by conjugating an anticancer drug on beta-glucans using a disulfide-containing linker. Following oral administration in glioma-bearing mice, the as-prepared prodrug can specifically target intestinal M cells, transpass the IEB, and be phagocytosed/hitchhiked by local macrophages (M phi). The M phi-hitchhiked prodrug is transported to the circulatory system via the lymphatic system, crossing the BBB. The tumor-overexpressed glutathione then cleaves the disulfide bond within the prodrug, releasing the active drug, improving its therapeutic efficacy. These findings reveal that the developed prodrug may serve as a gut-to-brain oral drug delivery platform for the well-targeted treatment of gliomas.
    日期: 2021-08
    關聯: Advanced Materials. 2021 Aug;33(34):Article number e2100701.
    Link to: http://dx.doi.org/10.1002/adma.202100701
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0935-9648&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000672883700001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85110250152
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