國家衛生研究院 NHRI:Item 3990099045/13523
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    題名: Adjuvant versus neoadjuvant immunotherapy for hepatocellular carcinoma: Clinical and immunologic perspectives
    作者: Su, YY;Li, CC;Lin, YJ;Hsu, C
    貢獻者: National Institute of Cancer Research
    摘要: Advancement in systemic therapy, particularly immune checkpoint inhibitor (ICI)-based combination regimens, has transformed the treatment landscape for patients with advanced hepatocellular carcinoma (HCC). The advancement in systemic therapy also provides new opportunities of reducing recurrence after curative therapy through adjuvant therapy or improving resectability through neoadjuvant therapy. Improved recurrence-free survival by adjuvant or neoadjuvant ICI-based therapy has been reported in other cancer types. In this article, developments of systemic therapy in adjuvant and neoadjuvant settings for HCC were reviewed. The design of adjuvant and neoadjuvant therapy using ICI-based regimens and potential challenges of trial conduct and result analysis was discussed. Results from these trials may extend the therapeutic benefit of ICI-based systemic therapy beyond the advanced-stage disease and lead to a new era of multidisciplinary management for HCC.
    日期: 2021-08
    關聯: Seminars in Liver Disease. 2021 Aug;41(3):263-276.
    Link to: http://dx.doi.org/10.1055/s-0041-1730949
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0272-8087&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000661614900003
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85108518942
    顯示於類別:[蘇勇曄] 期刊論文

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