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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13482


    Title: Longitudinal changes in physical and mental health of older adults with chronic hepatitis B infection: Trajectories and predictors
    Authors: Chen, CH;Wu, MS;Yang, YW;Liu, YT;Chiu, YF;Hsu, CC;Chuang, SC;Chung, TC;Tsai, TL;Huang, WH
    Contributors: Institute of Population Health Sciences
    Abstract: Despite the increasing health burden of chronic hepatitis B (CHB) in aging populations, little is known about the course of health-related quality of life (HRQoL) changes. We aimed to assess individual-level longitudinal HRQoL changes in elderly patients with CHB and to examine their correlates. A prospective 5.1 years-cohort study was conducted in community-dwelling adults aged 55 years with hepatitis B surface antigen-positive. Participants underwent serial measurement of HRQoL using the short-form (12) health survey version 2. Of 503 participants, 82.7% remained in good physical health throughout the study period, whereas 9.1% had declining physical health and 8.2% were in poor physical health. We likewise identified three trajectories of mental health changes (“good mental health” [86.9%], “declining mental health” [6.8%], and “poor mental health” [6.4%]). Three baseline characteristics were independently associated with a lower likelihood of remaining physically or mentally healthy: sarcopenic obesity (odds ratio [OR] with 95% confidence interval [95% CI] of 7.5 [2.8–20.5] for poor physical health, 3.1 [1.1–8.4] for declining physical health, 4.3 [1.4–13.0] for poor mental health), a higher number of metabolic abnormalities (OR [95% CI] of 3.6 [1.6–8.0] for poor physical health) and depressed mood (OR [95% CI] of 21.7 [5.8–81.0] for poor physical health, 5.3 [1.4–19.9] for declining physical health, 83.1 [19.7–350.2] for poor mental health, 13.6 [2.9–64.8] for declining mental health). In conclusion, in a cohort of elderly patients with CHB, we demonstrated the heterogeneity and nonlinearity of HRQoL changes and their associations with variations in specific extrahepatic organs/systems.
    Date: 2021-09
    Relation: Preventive Medicine Reports. 2021 Sep;23:Article number 101432.
    Link to: https://doi.org/10.1016/j.pmedr.2021.101432
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2211-3355&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000684860600022
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85107630855
    Appears in Collections:[吳易謙] 期刊論文
    [熊昭] 期刊論文
    [莊淑鈞] 期刊論文
    [許志成] 期刊論文
    [邱燕楓] 期刊論文

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