國家衛生研究院 NHRI:Item 3990099045/1347
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    题名: Combination of conformal radiotherapy and intratumoral injection of adoptive dendritic cell immunotherapy in refractory hepatoma
    作者: Chi, KW;Liu, SD;Li, CP;Kuo, HP;Wang, YS;Chao, Y;Hsieh, SL
    贡献者: Vaccine Research and Development Center
    摘要: A phase I study was conducted to assess the safety and immunologic response induced by direct injection of autologous immature dendritic cells (DCs) into tumor under radiotherapy in advanced hepatoma patients. Patients with advanced/rnetastatic stage hepatoma not suitable for surgery or transarterial embolization were enrolled. Groups of patients received two vaccinations. Each vaccination consisted of intratumoral injections of autologous immature DCs in four dose cohorts of 5 X 10(6), 1.5 X 10(7) 3 X 10(7), and 5 X 10(7) cells 2 days after a single fraction of conformal radiotherapy of 8 Gy. The second vaccination was performed 3 weeks later. Of the 14 patients entered, 12 completed two cycles of vaccination. The treatment was well tolerated at any of the dose levels. Six patients had mild transient fever (grade 1-2) with chill reactions, three patients developed grade I fatigue, and one patient developed mild myalgia and arthralgia after DC injections. There was no evidence of clinically manifested autoimmune disease. There were two partial responses and four minor responses. A decrease in the alpha-fetoprotein (AFP) level of more than 50% was found in three patients. Ten patients had completed immunologic response evaluation 2 weeks after the second cycle of vaccination. The AFP-specific immune response was evident in eight patients examined by cytokine release assay and in seven patients by ELISPOT assay. Six patients showed an increased NK cell cytotoxic activity after vaccination. These data suggest that the combination of intraturnoral injection of DCs and conformal radiotherapy is safe and can induce tumor-specific and innate immunity.
    关键词: Oncology;Immunology;Medicine, Research & Experimental
    日期: 2005-03
    關聯: Journal of Immunotherapy. 2005 Mar-Apr;28(2):129-135.
    Link to: http://journals.lww.com/immunotherapy-journal/pages/articleviewer.aspx?year=2005&issue=03000&article=00003&type=abstract
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1524-9557&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000227392000002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=14744275172
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