國家衛生研究院 NHRI:Item 3990099045/13477
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    题名: Adequate surgical margins for oral cancer: A Taiwan cancer registry national database analysis
    作者: Lin, MC;Leu, YS;Chiang, CJ;Ko, JY;Wang, CP;Yang, TL;Chen, TC;Chen, CN;Chen, HL;Liao, CT;Tsai, ST;Lin, JC;Chu, PY;Tsai, KY;Tsai, MH;Huang, HC;Yang, MH;Wu, YH;Terng, SD;Chien, CY;Liu, TW;Lee, WC;Lou, PJ
    贡献者: National Institute of Cancer Research
    摘要: BACKGROUND: Margin status and lymph node metastasis are the most important prognostic factors for oral cancers. However, while adequate surgical resection is crucial for local control and prognosis, the definition of clear margins has long been a subject of debate. In this study, we analyzed data from a nationwide population-based cancer registry database and evaluated the impact of surgical margins on cancer-specific survival (CSS) and overall survival (OS) as well as the optimal cutoff of adequate surgical margins. METHODS: This analysis included all cases of oral cancer diagnosed from 2011 to 2017 that were reported to the Taiwan Cancer Registry database. The staging system was converted from American Joint Committee on Cancer (AJCC) version 7 to AJCC version 8. Kaplan-Meier analysis and Cox proportional-hazards regression were performed to identify covariates that were significantly associated with CSS and OS. RESULTS: Between 2011 and 2017, 15,654 of a total of 36,091 cases diagnosed with oral cancers were included in the final analyses. Advanced N stage, positive margins, and advanced T stage are the leading risk factors for poor CSS and OS. When surgical margins were subdivided into 1-mm intervals from 5 mm to positive margin, we found that surgical margins <4 mm and <5 mm predict poor CSS and OS, respectively. CONCLUSIONS: This is the first nationwide, population-based cohort to revisit the question of the adequate surgical margins for oral cancers. We conclude that surgical margins ≥4 mm and ≥5 mm are adequate for good CSS and OS, respectively.
    日期: 2021-05-26
    關聯: Oral Oncology. 2021 May 26;119:Article number 105358.
    Link to: http://dx.doi.org/10.1016/j.oraloncology.2021.105358
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1368-8375&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000675836400009
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85106931039
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