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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/13449
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| Title: | Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila |
| Authors: | Lee, TT;Chen, PL;Su, MP;Li, JC;Chang, YW;Liu, RW;Juan, HF;Yang, JM;Chan, SP;Tsai, YC;von Stockum, S;Ziviani, E;Kamikouchi, A;Wang, HD;Chen, CH |
| Contributors: | National Institute of Infectious Diseases and Vaccinology;National Mosquito-Borne Diseases Control Research Center |
| Abstract: | Increased levels of dysfunctional mitochondria within skeletal muscle are correlated with numerous age-related physiopathological conditions. Improving our understanding of the links between mitochondrial function and muscle proteostasis, and the role played by individual genes and regulatory networks, is essential to develop treatments for these conditions. One potential player is the mitochondrial outer membrane protein Fis1, a crucial fission factor heavily involved in mitochondrial dynamics in yeast but with an unknown role in higher-order organisms. By using Drosophila melanogaster as a model, we explored the effect of Fis1 mutations generated by transposon Minos-mediated integration. Mutants exhibited a higher ratio of damaged mitochondria with age as well as elevated reactive oxygen species levels compared with controls. This caused an increase in oxidative stress, resulting in large accumulations of ubiquitinated proteins, accelerated muscle function decline, and mitochondrial myopathies in young mutant flies. Ectopic expression of Fis1 isoforms was sufficient to suppress this phenotype. Loss of Fis1 led to unbalanced mitochondrial proteostasis within fly muscle, decreasing both flight capabilities and lifespan. Fis1 thus clearly plays a role in fly mitochondrial dynamics. Further investigations into the detailed function of Fis1 are necessary for exploring how mitochondrial function correlates with muscle health during aging. |
| Date: | 2021-06-01 |
| Relation: | Aging Cell. 2021 Jun 1;20(6):Article number 13379. |
| Link to: | http://dx.doi.org/10.1111/acel.13379 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1474-9718&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000656535700001 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85107318704 |
| Appears in Collections: | [陳俊宏] 期刊論文
[其他] 期刊論文
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| PUB34061429.pdf | | 2328Kb | Adobe PDF | 323 | View/Open |
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