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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/13438
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| Title: | Differential mechanisms of synaptic plasticity for susceptibility and resilience to chronic social defeat stress in male mice |
| Authors: | Lee, CW;Fang, YP;Chu, MC;Chung, YJ;Chi, H;Tang, CW;So, EC;Lin, HC;Lin, HC |
| Contributors: | NHRI Graduate Student Program |
| Abstract: | Mood dysregulation refers to the inability of a person to control their negative emotions, and it is linked to various stressful experiences. Dysregulated neural synaptic plasticity and actin -filament dynamics are important regulators of stress response in animal models. However, until now, there is no evidence to differential the mechanisms of synaptic plasticity and actin -filament dynamics in stress susceptibility and stress-resistant. Here we found that depression-like behaviour was observed in the susceptible group following chronic social defeat stress (CSDS) exposure, but not in stress-resistant mice. High frequency stimulation-induced long-term potentiation (LTP) was impaired in the CSDS-induced depression-susceptible group. Further, the levels of pro-brain derived neurotrophic factor (BDNF), mature BDNF, PSD-95, phosphorylated CaMKII, and phosphorylated Cofilin, an actin -filament dynamics regulator, were reduced in CSDS-induced depression-susceptible mice unlike in stress-resistant mice. These results demonstrate that synaptic plasticity-related molecules, such as BDNF and phosphorylated Cofilin, are important for maintaining synaptic functions and structure in mice that experience more stress.& nbsp |
| Date: | 2021-07-12 |
| Relation: | Biochemical and Biophysical Research Communications. 2021 Jul 12;562:112-118. |
| Link to: | http://dx.doi.org/10.1016/j.bbrc.2021.05.064 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0006-291X&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000654711400003 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85106515744 |
| Appears in Collections: | [其他] 期刊論文
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| ISI000654711400003.pdf | | 1110Kb | Adobe PDF | 218 | View/Open |
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