Loading...
|
Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/13420
|
| Title: | Salvage boron neutron capture therapy for malignant brain tumor patients in compliance with emergency and compassionate use: Evaluation of 34 cases in Taiwan |
| Authors: | Chen, YW;Lee, YY;Lin, CF;Pan, PS;Chen, JK;Wang, CW;Hsu, SM;Kuo, YC;Lan, TL;Hsu, SPC;Liang, ML;Chen, RH;Chang, FC;Wu, CC;Lin, SC;Liang, HK;Lee, JC;Chen, SK;Liu, HM;Peir, JJ;Lin, KH;Huang, WS;Chen, KH;Kang, YM;Liou, SC;Wang, CC;Pai, PC;Li, CW;Chiek, DQS;Wong, TT;Chiou, SH;Chao, Y;Tanaka, H;Chou, FI;Ono, K |
| Contributors: | Institute of Biomedical Engineering and Nanomedicine |
| Abstract: | Although boron neutron capture therapy (BNCT) is a promising treatment option for malignant brain tumors, the optimal BNCT parameters for patients with immediately life-threatening, end-stage brain tumors remain unclear. We performed BNCT on 34 patients with life-threatening, end-stage brain tumors and analyzed the relationship between survival outcomes and BNCT parameters. Before BNCT, MRI and (18)F-BPA-PET analyses were conducted to identify the tumor location/distribution and the tumor-to-normal tissue uptake ratio (T/N ratio) of (18)F-BPA. No severe adverse events were observed (grade ≥ 3). The objective response rate and disease control rate were 50.0% and 85.3%, respectively. The mean overall survival (OS), cancer-specific survival (CSS), and relapse-free survival (RFS) times were 7.25, 7.80, and 4.18 months, respectively. Remarkably, the mean OS, CSS, and RFS of patients who achieved a complete response were 17.66, 22.5, and 7.50 months, respectively. Kaplan-Meier analysis identified the optimal BNCT parameters and tumor characteristics of these patients, including a T/N ratio ≥ 4, tumor volume < 20 mL, mean tumor dose ≥ 25 Gy-E, MIB-1 ≤ 40, and a lower recursive partitioning analysis (RPA) class. In conclusion, for malignant brain tumor patients who have exhausted all available treatment options and who are in an immediately life-threatening condition, BNCT may be considered as a therapeutic approach to prolong survival. |
| Date: | 2021-04-15 |
| Relation: | Biology. 2021 Apr 15;10(4):Article number 334. |
| Link to: | http://dx.doi.org/10.3390/biology10040334 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2079-7737&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000642723500001 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85104952726 |
| Appears in Collections: | [陳仁焜] 期刊論文
|
Files in This Item:
| File |
Description |
Size | Format | |
|---|
| PUB33920984.pdf | | 3712Kb | Adobe PDF | 271 | View/Open |
|
All items in NHRI are protected by copyright, with all rights reserved.
|
