國家衛生研究院 NHRI:Item 3990099045/13417

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Title:	Curcumin-loaded hydrophobic surface-modified hydroxyapatite as an antioxidant for sarcopenia prevention
Authors:	Liang, YJ;Yang, IH;Lin, YW;Lin, JN;Wu, CC;Chiang, CY;Lai, KH;Lin, FH
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	Oxidative stress and later-induced chronic inflammation have been reported to play an important role on the progression of sarcopenia. Current treatments for sarcopenia are mainly ad-ministered to patients whom sarcopenia already developed. However, there has been no promising results shown in therapy. Therefore, the development of therapeutic and preventive strategies against sarcopenia would be necessary. Curcumin is a traditional medicine that possesses anti-in-flammatory and anti-oxidative properties. In the present study, hydroxyapatite was subjected to hydrophobic surface modifications for curcumin loading (Cur-SHAP). It was, subsequently, uti-lized for delivery to the patient’s body via intramuscular injection in order to achieve constant release for more than 2 weeks, preventing the progression of the sarcopenia or even leading to recovery from the early stage of the illness. According to the results of WST-1, LIVE/DEAD, DCFDA, and gene expression assays, Cur-SHAP exhibited good biocompatibility and showed great antioxi-dant/anti-inflammatory effects through the endocytic pathway. The results of the animal studies showed that the muscle endurance, grip strength, and fat/lean mass ratio were all improved in Cur-SHAP-treated rats from LPS-induced sarcopenia. In summary, we successfully synthesized hydro-phobic surface modification hydroxyapatite for curcumin loading (Cur-SHAP) and drug delivery via the IM route. The LPS-induced sarcopenia rats were able to recover from disease after the Cur-SHAP treatment.
Date:	2021-04-16
Relation:	Antioxidants. 2021 Apr 16;10(4):Article number 616.
Link to:	http://dx.doi.org/10.3390/antiox10040616
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2076-3921&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000642740100001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85104491114
Appears in Collections:	[Feng-Huei Lin] Periodical Articles

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